*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UE9458000
CHEMICAL NAME           : Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, ester
                          with 4-hydroxy-N,N-dimethylbutyramide
CAS REGISTRY NUMBER     : 26717-47-5
BEILSTEIN REFERENCE NO. : 2008046
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C16-H22-Cl-N-O4
MOLECULAR WEIGHT        : 327.84
WISWESSER LINE NOTATION : GR DOX1&1&VO3VN1&1
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Butyramide, N-dimethyl-4-(p-chlorophenoxyisobutyrate)
   * Chloro-4 phenoxyisobutyrate d'hydroxy-4 N-dimethylbutyramide
   * N-Dimethyl-4-(p-chlorophenoxy-1,1'-dimethylacetate)butyramide
   * N-Dimethyl-4-(1,4'-chlorophenoxy-1,1'-dimethylacetate)butyramide
   * N-Dimethyl-4-(p-chlorophenoxyisobutyrate)butyramide
   * N-Dimethyl-4-(1,4'-chlorophenoxyisobutyrate)butyramide
   * 4-Hydroxy-N-dimethylbutyramide-4-chlorophenoxy-isobutyrate
   * Lipenan
   * MG 46
   * Propionic acid, 2-(4-chlorophenoxy)-2-methyl-,  
   4-(dimethylamino)-4-oxobutyl ester
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2485 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JETOAS Journal Europeen de Toxicologie.  (Paris, France)  V.1-6, 1968-72.
   For publisher information, see TOERD9.  Volume(issue)/page/year: 5,239,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1175 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JETOAS Journal Europeen de Toxicologie.  (Paris, France)  V.1-6, 1968-72.
   For publisher information, see TOERD9.  Volume(issue)/page/year: 5,239,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1080 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JETOAS Journal Europeen de Toxicologie.  (Paris, France)  V.1-6, 1968-72.
   For publisher information, see TOERD9.  Volume(issue)/page/year: 5,239,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 960 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JETOAS Journal Europeen de Toxicologie.  (Paris, France)  V.1-6, 1968-72.
   For publisher information, see TOERD9.  Volume(issue)/page/year: 5,239,1972
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 14 gm/kg
SEX/DURATION            : male 7 day(s) pre-mating
                          female 7 day(s) pre-mating
                          female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
REFERENCE :
   JETOAS Journal Europeen de Toxicologie.  (Paris, France)  V.1-6, 1968-72.
   For publisher information, see TOERD9.  Volume(issue)/page/year: 5,239,1972
 
                            *** END OF RECORD ***