*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : UD3550000
CHEMICAL NAME : 2-Propenoic acid,
3-(6-(methylthio)-4-oxo-3(4H)-quinazolinyl)-, (E)-
CAS REGISTRY NUMBER : 78299-53-3
BEILSTEIN REFERENCE NO. : 5752117
LAST UPDATED : 199612
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C12-H10-N2-O3-S
MOLECULAR WEIGHT : 262.30
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* (E)-6-(Methylthio)-4-oxo-3(4H)-quinazolineacrylic acid
* (E)-3-(6-(Methylthio)-4-oxo-3(4H)-quinazolinyl)-2-propenoic acid
* Ro 22-3747
* Tiacrilast
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
10,131,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
10,131,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
10,131,1985
*** END OF RECORD ***