*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UC8325000
CHEMICAL NAME           : Propene, 1,3-dichloro-, (Z)-
CAS REGISTRY NUMBER     : 10061-01-5
BEILSTEIN REFERENCE NO. : 1719557
REFERENCE               : 4-01-00-00743 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C3-H4-Cl2
MOLECULAR WEIGHT        : 110.97
WISWESSER LINE NOTATION : G2U1G -C
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * cis-1,3-Dichloropropene
   * (Z)-1,3-Dichloropropene
   * (Z)-1,3-Dichloro-1-propene
   * cis-1,3-Dichloropropylene
   * 1-Propene, 1,3-dichloro-, (Z)-
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 9240 mg/kg/77W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 63,1433,1979
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 20 ug/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   37,1915,1977
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 100 umol/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   20,263,1983

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-GERMANY;Carcinogen JAN 1993
   
   OEL-SWITZERLAND:TWA 1 ppm (5 mg/m3);Skin;Carcinogen JAN 1993

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***