*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UC3098000
CHEMICAL NAME           : 1-Propanone,
                          2-methyl-3-(1-pyrrolidinyl)-1-(4-(trifluoromethyl)phe
                          nyl)-, hydrochloride, (R)-
CAS REGISTRY NUMBER     : 116287-13-9
LAST UPDATED            : 199703
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C15-H18-F3-N-O.Cl-H
MOLECULAR WEIGHT        : 321.80
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Lanperisone hydrochloride
   * (R)-2-Methyl-3-(1-pyrrolidinyl)-1-(4-(trifluoromethyl)phenyl)-1-propanone 
    hydrochloride
   * 2-Methyl-3-(1-pyrrolidinyl)-4'-trifluoromethylpropiophenone  
   monohydrochloride
   * (-)-(R)-2-Methyl-3-(1-pyrrolidinyl)-4'-trifluoromethylpropiophenone  
   monohydrochloride
   * NK433
   * NK433 hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 525 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 50,461,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 49 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 50,461,1995
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3039 mg/kg/26W-I
TOXIC EFFECTS :
   Gastrointestinal - changes in structure or function of salivary glands
   Liver - fatty liver degeneration
   Liver - changes in liver weight
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 50,467,1995
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 2800 mg/kg/4W-I
TOXIC EFFECTS :
   Gastrointestinal - changes in structure or function of salivary glands
   Kidney, Ureter, Bladder - changes in bladder weight
   Endocrine - changes in adrenal weight
REFERENCE :
   JZKEDZ Jitchuken Zenrinsho Kenkyuho.  Central Institute for Experimental
   Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
   Takatsu-ku, Kawasaki 211, Japan)  V.1-    1975-  Volume(issue)/page/year:
   20,37,1995
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 9100 mg/kg/26W-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Liver - changes in liver weight
REFERENCE :
   JZKEDZ Jitchuken Zenrinsho Kenkyuho.  Central Institute for Experimental
   Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
   Takatsu-ku, Kawasaki 211, Japan)  V.1-    1975-  Volume(issue)/page/year:
   20,55,1995
 
                            *** END OF RECORD ***