*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UC1575000
CHEMICAL NAME           : 2-Propanone, 1,3-dichloro-1,1,3,3-tetrafluoro-
CAS REGISTRY NUMBER     : 127-21-9
BEILSTEIN REFERENCE NO. : 0509313
REFERENCE               : 4-01-00-03221 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C3-Cl2-F4-O
MOLECULAR WEIGHT        : 198.93
WISWESSER LINE NOTATION : GXFFVXGFF
COMPOUND DESCRIPTOR     : Agricultural Chemical
SYNONYMS/TRADE NAMES :
   * Acetone, 1,3-dichloro-1,1,3,3-tetrafluoroacetone
   * Dichlorotetrafluoroacetone
   * sym-Dichlorotetrafluoroacetone
   * 1,3-Dichloro-1,1,3,3-tetrafluoro-2-propanone
   * 4FK
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 61 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   7,592,1965
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4800 mg/m3
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo
   Instituta.  (Leningrad, Russia) V.1-145, 1949-82.  Discontinued.
   Volume(issue)/page/year: 111,15,1975
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4500 mg/m3
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo
   Instituta.  (Leningrad, Russia) V.1-145, 1949-82.  Discontinued.
   Volume(issue)/page/year: 111,15,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#01749
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 91 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - primary irritation (after topical exposure)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   7,592,1965

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-RUSSIA:STEL 2 mg/m3;Skin JAN 1993

                          *** STATUS IN U.S. ***
 
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***