*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : UA9458000
CHEMICAL NAME : 2-Propanol,
1-((7-chloro-4-quinolinyl)amino)-3-(diethylamino)-,
diphosphate
LAST UPDATED : 199606
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C16-H22-Cl-N3-O.2H3-O4-P
MOLECULAR WEIGHT : 503.86
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* 1-((7-Chloro-4-quinolinyl)amino)-3-(diethylamino)-2-propanol diphosphate
* SN 8137
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2
vols., Ann Arbor, MI, J.W. Edwards, 1946 Volume(issue)/page/year:
1,393,1946
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 2240 mg/kg/14D-I
TOXIC EFFECTS :
Behavioral - coma
Liver - fatty liver degeneration
Related to Chronic Data - death
REFERENCE :
85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2
vols., Ann Arbor, MI, J.W. Edwards, 1946 Volume(issue)/page/year:
1,393,1946
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 1900 mg/kg/19D-I
TOXIC EFFECTS :
Behavioral - muscle weakness
Liver - fatty liver degeneration
Related to Chronic Data - death
REFERENCE :
85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2
vols., Ann Arbor, MI, J.W. Edwards, 1946 Volume(issue)/page/year:
1,393,1946
*** END OF RECORD ***