*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EV6495400
CHEMICAL NAME           : 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, mixt.
                          with 3,7-dihydro-1,3,7-trimethyl-1H- purine-2,6-dione
CAS REGISTRY NUMBER     : 69-22-7
OTHER CAS REGISTRY NOS. : 2406-91-9
LAST UPDATED            : 199710
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C8-H10-N4-O2.C6-H8-O7
MOLECULAR WEIGHT        : 386.36
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Caffeina citrate
   * Caffeine citrate
   * Caffeine citrate (1:1)
   * Citrated caffein
   * Citric acid, compd. with caffeine (1:1)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 27,1048,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 356 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 17,196,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 540 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #3755326
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 49 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 17,196,1961
 
                            *** END OF RECORD ***