*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TZ2575000
CHEMICAL NAME           : 1,3-Propanedisulfonic acid,
                          1-phenyl-3-(p-2-pyridylsulfamoylanilino)-, disodium
                          salt
CAS REGISTRY NUMBER     : 53778-51-1
LAST UPDATED            : 198706
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C20-H19-N3-O8-S3.2Na
MOLECULAR WEIGHT        : 571.58
WISWESSER LINE NOTATION : T6NJ BMSWR DMYSWO&1YR&SWO &-NA- 2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Disodium cinnamylidene bisulfite deriv. of sulfapyridine
   * Disodium 2-(p-(gamma-phenylpropylamino)benzenesulfonamido)pyridine
   * 1-Phenyl-3-(p-2-pyridylsulfamoylanilino)-1,3-propanedisulfonic acid  
   disodium salt
   * Solupyridine
   * Sulfapyridine neutral soluble
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7500 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 84,203,1945
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2680 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 84,203,1945
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1280 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 84,203,1945
 
                            *** END OF RECORD ***