*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TZ1070000
CHEMICAL NAME           : 1,3-Propanediol, 2-phenyl-, dicarbamate
CAS REGISTRY NUMBER     : 25451-15-4
BEILSTEIN REFERENCE NO. : 3345236
REFERENCE               : 4-06-00-05993 (Beilstein Handbook Reference)
LAST UPDATED            : 199806
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C11-H14-N2-O4
MOLECULAR WEIGHT        : 238.27
WISWESSER LINE NOTATION : ZVO1YR&1OVZ
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Carbamic acid, 2-phenyltrimethylene ester
   * Felbamate
   * Felbamato
   * 2-Phenyl-1,3-propanediol dicarbamate
   * W 554
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Behavioral - sleep
REFERENCE :
   PECAE5 Pediatric Emergency Care.  (Williams & Wilkins, 428 E. Preston St.,
   Baltimore, MD  21202) V.1-    1985-  Volume(issue)/page/year: 11,369,1995
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1296 mg/kg/18D-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Gastrointestinal - other changes
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   PHPYDQ Pharmacotherapy (Carlisle, MA).  (Pharmacotherapy Pub., Inc., 112
   School St., Carlisle, MA 01741)  V.1-    1981-  Volume(issue)/page/year:
   15,260,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   11,931,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   11,931,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 12,462,1969
 
                            *** END OF RECORD ***