*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : TY8750000
CHEMICAL NAME : 1,2-Propanediol, 3-(o-methoxyphenoxy)-, 1-carbamate
CAS REGISTRY NUMBER : 532-03-6
BEILSTEIN REFERENCE NO. : 1884446
REFERENCE : 4-06-00-05577 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C11-H15-N-O5
MOLECULAR WEIGHT : 241.27
WISWESSER LINE NOTATION : ZVO1YQ1OR BO1
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* AHR 85
* Avetil
* Carbamic acid, 2-hydroxy-3-(o-methoxyphenoxy)propyl ester
* Etroflex
* Glycerylguaiacolate carbamate
* Glycerylguajacol-carbamat
* Guaiacol glyceryl ether carbamate
* Guiacol-gliceriletere monocarbammato
* 2-Hydroxy-3-(o-methoxyphenoxy)propyl 1-carbamate
* Lumirelax
* Methocarbamol
* 3-(2-Methoxyphenoxy)-1-glyceryl carbamate
* 3-(o-Methoxyphenoxy)-2-hydroxypropyl carbamate
* 3-(o-Methoxyphenoxy)-1,2-propanediol 1-carbamate
* Metocarbamol
* Metocarbamolo
* Metofenina
* Miolaxene
* Miorilas
* Miowas
* Myolaxene
* Neuraxin
* Reflexyn
* Relestrid
* Robaxin
* Robaxine
* Robinax
* Surquetil
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1320 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 129,75,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 815 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 17,242,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 812 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,836,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 950 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
2,264,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 780 mg/kg
TOXIC EFFECTS :
Behavioral - anticonvulsant
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
19,247,1962
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 774 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,836,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,398,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 680 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - rigidity (including catalepsy)
REFERENCE :
IJNEAQ International Journal of Neuropharmacology. (New York, NY) V.1-8,
1962-69. For publisher information, see NEPHBW. Volume(issue)/page/year:
5,305,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 1410 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 129,75,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 1050 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 129,75,1960
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84354
No. of Facilities: 350 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 1853 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84354
No. of Facilities: 188 (estimated)
No. of Industries: 1
No. of Occupations: 4
No. of Employees: 9546 (estimated)
No. of Female Employees: 8341 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***