*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TY3700000
CHEMICAL NAME           : 1,3-Propanediol, 2-(tert-butyl)-2-(hydroxymethyl)-,
                          cyclic phosphate (1:1)
CAS REGISTRY NUMBER     : 61481-19-4
BEILSTEIN REFERENCE NO. : 2329390
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C8-H15-O4-P
MOLECULAR WEIGHT        : 206.20
WISWESSER LINE NOTATION : T66 A B AO EOPOTJ CX1&1&1 FO
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * t-Butyl-bicyclophosphate
   * 2-(tert-Butyl)-2-(hydroxymethyl)-1,3-propanediol, cyclic phosphate (1:1)
   * 4-t-Butyl-1-oxo-1-phospha-2,6,7-trioxabicyclo(2.2.2)octane
   * 4-(tert-Butyl)-2,6,7-trioxa-1-phosphabicyclo(2.2.2)octan-1-one
   * 2,6,7-Trioxa-1-phosphabicyclo(2.2.2)octan-1-one, 4-(tert-butyl)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 35 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   46,411,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 45 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   46,411,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 35 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   46,411,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 120 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 13,207,1978
 
                            *** END OF RECORD ***