*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TX7955000
CHEMICAL NAME           : 1,2-Propanediamine, N(sup 1),N(sup 1)-dimethyl-N(sup
                          2)-(1-nitro-9-acridinyl)-, dihydrochloride
CAS REGISTRY NUMBER     : 65094-73-7
LAST UPDATED            : 198910
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C18-H20-N4-O2.2Cl-H
MOLECULAR WEIGHT        : 397.34
WISWESSER LINE NOTATION : T C666 BNJ GNW IMY1&1N1&1 &GH 2
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Acridine, 9-((2-(dimethylamino)-1-methylethyl)amino)-1-nitro,  
   hydrochloride
   * C-829
   * Dihydrochloride 1-nitro-9-((2-dimethylamino)-1-methylethylamino)-acridine
   * 9-((2-(Dimethylamino)-1-methylethyl)amino)-1-nitroacridine  
   dihydrochloride
   * N-Dimethyl-1-methyl-N'-(1-nitro-9-acridinyl)-1,2-ethanediamine  
   dihydrochloride
   * 1,2-Ethanediamine, N'-(1-nitro-9-acridinyl)-N,N,1-trimethyl-,  
   hydrochloride
   * 1-Nitro-9-((2-dimethylamino)-1-methylethylamino)-acridine dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 105 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - decreased motility or constipation
   Gastrointestinal - other changes
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   27,749,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   27,749,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 99200 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - decreased motility or constipation
   Gastrointestinal - other changes
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   27,749,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 21300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   27,749,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 21 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   28,777,1980
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 80 nmol/L/69H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 67,93,1979
 
                            *** END OF RECORD ***