*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TX7033850
CHEMICAL NAME           : 1,3-Propanediamine,
                          N-(2-butoxy-7-chlorobenzo(b)-1,5-naphthyridin-10-yl)-
                          N'-(2- chloroethyl)-, dihydrochloride, hydrate (4:3)
CAS REGISTRY NUMBER     : 38915-38-7
LAST UPDATED            : 199707
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C21-H26-Cl2-N4-O.2Cl-H.3/4H2-O
MOLECULAR WEIGHT        : 507.85
WISWESSER LINE NOTATION : T C666 BN GNJ FO4 IM3M2G MG &GH 2 &QH 3/4
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * ICR 371 dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD20 - Lethal Dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 51 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 15,739,1972

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation

 
                            *** END OF RECORD ***