*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TX7032500
CHEMICAL NAME           : 1,3-Propanediamine,
                          N-(2-butoxy-7-chlorobenzo(b)-1,5-naphthyridin-10-yl)-
                          N'-(2-chloroethyl)- N'-ethyl-, dihydrochloride,
                          hydrate
CAS REGISTRY NUMBER     : 38915-40-1
LAST UPDATED            : 199304
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C23-H30-Cl2-N4-O.2Cl-H.H2-O
MOLECULAR WEIGHT        : 539.40
WISWESSER LINE NOTATION : T C666 BN GNJ FO4 IM3N2&2G MG &GH 2 &QH
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * ICR 355
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD20 - Lethal Dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 16 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 15,739,1972
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 ng/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 136,185,1984
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 1 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,4875,1979

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation

 
                            *** END OF RECORD ***