*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : TX3800000
CHEMICAL NAME : Propane, 2,2-bis(p-(2,3-epoxypropoxy)phenyl)-
CAS REGISTRY NUMBER : 1675-54-3
LAST UPDATED : 199710
DATA ITEMS CITED : 22
MOLECULAR FORMULA : C21-H24-O4
MOLECULAR WEIGHT : 340.45
WISWESSER LINE NOTATION : T3OTJ B1OR D- 2X
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* 2,2-Bis(4-(2,3-epoxypropyloxy)phenyl)propane
* Bis(4-glycidyloxyphenyl)dimethyamethane
* 2,2-Bis(p-glycidyloxyphenyl)propane
* 2,2-Bis(4-hydroxyphenyl)propane, diglycidyl ether
* Bis(4-hydroxyphenyl)dimethylmethane diglycidyl ether
* 2,2-Bis(p-hydroxyphenyl)propane, diglycidyl ether
* Bisphenol A diglycidyl ether
* Bpdge
* D.E.R. 332
* Dian-bis-glycidylether
* Dian diglycidyl ether
* Diglycidyl bisphenol A ether
* Diglycidyl ether of 2,2-bis(p-hydroxyphenyl)propane
* Diglycidyl ether of 2,2-bis(4-hydroxyphenyl)propane
* Diglycidyl ether of bisphenol A
* Diglycidyl ether of 4,4'-isopropylidenediphenol
* 4,4'-Dihydroxydiphenyldimethylmethane diglycidyl ether
* p,p'-Dihydroxydiphenyldimethylmethane diglycidyl ether
* Diomethane diglycidyl ether
* Epi-Rez 508
* Epi-Rez 510
* Epotuf 37-140
* Epoxide A
* ERL-2774
* GY 6010
* 4,4'-Isopropylidenediphenol diglycidyl ether
* 2,2'-((1-Methylethylidene)bis(4,1-phenyleneoxymethylene))bisoxirane
* Oligomer 340
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Open irritation test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg
REACTION SEVERITY : Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 4/21/1967
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2 mg/24H
REACTION SEVERITY : Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,782,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 11300 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 4/21/1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2A,2219,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 15600 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2A,2219,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2A,2219,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1980 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2A,2219,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 20 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2A,2219,1981
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 166 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Endocrine - thyroid tumors
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
26,611,1988
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 312 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Reproductive - Tumorigenic effects - ovarian tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
39,1718,1979
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 312 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: ORNL-5375
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 33 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 172,105,1986
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 47,237,1989
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 47,237,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - T0018
No. of Facilities: 163 (estimated)
No. of Industries: 8
No. of Occupations: 10
No. of Employees: 1413 (estimated)
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83440
No. of Facilities: 2505 (estimated)
No. of Industries: 54
No. of Occupations: 54
No. of Employees: 32393 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83440
No. of Facilities: 1109 (estimated)
No. of Industries: 28
No. of Occupations: 38
No. of Employees: 25257 (estimated)
No. of Female Employees: 4341 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978
*** END OF RECORD ***