*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TX1404500
CHEMICAL NAME           : Propanamide, 2-amino-N-(2,6-dimethylphenyl)-,
                          monohydrochloride
CAS REGISTRY NUMBER     : 35891-93-1
LAST UPDATED            : 199706
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C11-H16-N2-O.Cl-H
MOLECULAR WEIGHT        : 228.75
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * 2-Amino-N-(2,6-dimethylphenyl)propanamide monohydrochloride
   * Tocainide hydrochloride
   * Tonocard hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 48 mg/kg/2D-I
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
REFERENCE :
   PGMJAO Postgraduate Medical Journal.  (Blackwell Scientific Pub. Ltd., POB
   88, Oxford, UK) V.1-    1925-  Volume(issue)/page/year: 61,79,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 257 mg/kg/15D-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Taste) - change in function
   Behavioral - tremor
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   DICPBB Drug Intelligence and Clinical Pharmacy.  (POB 42435, Cincinnati, OH
   45242)  V.3-    1969-  Volume(issue)/page/year: 22,142,1988
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 360 mg/kg/6W-I
TOXIC EFFECTS :
   Blood - normocytic anemia
   Blood - agranulocytosis
REFERENCE :
   AIMDAP Archives of Internal Medicine.  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-    1908-  Volume(issue)/page/year: 147,598,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 529 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHMCAA Pharmacologist.  (American Soc. for Pharmacology and Experimental
   Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014)  V.1-    1959-
   Volume(issue)/page/year: 15,192,1973
 
                            *** END OF RECORD ***