*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TW2895000
CHEMICAL NAME           : Prolactin
CAS REGISTRY NUMBER     : 9002-62-4
LAST UPDATED            : 199103
DATA ITEMS CITED        : 11
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * Adenohypophyseal luteotropin
   * Anterior pituitary luteotropin
   * Bovine lactogenic hormone
   * Bovine prolactin
   * Galctin
   * Lactogen
   * Lactogenic hormone
   * Lactosomatotropic hormone
   * Luteotrophin
   * Luteotropic hormone
   * Luteotropic Hormone LTH
   * Luteotropin
   * Mammotropin
   * Ovine prolactin
   * Paralctin
   * Pituitary lactogenic hormone
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 12500 ug/kg
SEX/DURATION            : female 16-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 94,746,1957
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 mg/kg
SEX/DURATION            : female 3 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   BIREBV Biology of Reproduction.  (Soc. for the Study of Reproduction, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1969-  Volume(issue)/page/year:
   10,327,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 57600 ug/kg
SEX/DURATION            : male 36 day(s) pre-mating
TOXIC EFFECTS :
   Endocrine - changes in luteinizing hormone
   Endocrine - androgenic
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   ARANDR Archives of Andrology.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1978- Volume(issue)/page/year:
   10,143,1983
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 625 ug/kg
SEX/DURATION            : female 8-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   83,1273,1968
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1250 ug/kg
SEX/DURATION            : female 6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 130,628,1969
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 36 mg/kg
SEX/DURATION            : female 9 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 16,1233,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 5 mg/kg
SEX/DURATION            : female 10 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   84,135P,1984
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 1 mg/kg
SEX/DURATION            : lactating female 1 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 262,507,1976
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Subcutaneous
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 40 mg/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,2223,1976
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Mammary gland
DOSE/DURATION           : 5 mg/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,2162,1976
 
TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Rodent - rabbit
DOSE/DURATION           : 62 ug/kg
REFERENCE :
   JNCSAI Journal of Cell Science.  (Biochemical Soc. Book Depot, POB 32,
   Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1966-
   Volume(issue)/page/year: 14,105,1974
 
                            *** END OF RECORD ***