*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TU5570260
CHEMICAL NAME           : 17-alpha-Pregn-4-en-20-yn-3-one, 17-hydroxy-, and
                          trans-alpha,alpha'-diethyl-4,4'- stilbenediol
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C21-H28-O2.C18-H20-O2
MOLECULAR WEIGHT        : 580.87
COMPOUND DESCRIPTOR     : Tumorigen
                          Reproductive Effector
                          Human
                          Hormone
SYNONYMS/TRADE NAMES :
   * Diethylstilbestrol and ethisterone
   * Diethylstilbestrol and pranone
   * Ethisterone and diethylstilbestrol
   * Pranone and diethylstilbestrol
   * Pranone and stilbestrol
   * Stilbestrol and pranone
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 164 mg/kg/9Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
   BJOGAS British Journal of Obstetrics and Gynaecology.  (Blackwell Scientific
   Pub. Ltd., POB 88, Oxford, UK)  V.82-    1975- Volume(issue)/page/year:
   82,421,1975
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 1050 mg/kg
SEX/DURATION            : female 4-36 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   JCEMAZ Journal of Clinical Endocrinology and Metabolism.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.12-    1952-
   Volume(issue)/page/year: 19,1369,1959
 
                            *** END OF RECORD ***