*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TU5513000
CHEMICAL NAME           : Pregn-4-ene-3,11,20-trione
CAS REGISTRY NUMBER     : 516-15-4
BEILSTEIN REFERENCE NO. : 2063775
REFERENCE               : 4-07-00-02800 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C21-H28-O3
MOLECULAR WEIGHT        : 328.49
WISWESSER LINE NOTATION : L E5 B666 CV OV MUTJ A1 E1 FV1
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * Ketogestin
   * Ketoprogesterone
   * 11-Ketoprogesterone
   * 11-Oxoprogesterone
   * U 1258
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 2500 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press,
   1965  Volume(issue)/page/year: -,111,1965
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 50 umol/L
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 146,401,1974
 
                            *** END OF RECORD ***