*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TU5025000
CHEMICAL NAME           : Pregn-4-ene-3,20-dione,
                          9-fluoro-11-beta,17,21-trihydroxy-
CAS REGISTRY NUMBER     : 127-31-1
BEILSTEIN REFERENCE NO. : 3014278
REFERENCE               : 4-08-00-03427 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C21-H29-F-O5
MOLECULAR WEIGHT        : 380.50
WISWESSER LINE NOTATION : L E5 B666 OV MUTJ A1 BF CQ E1 FV1Q FQ
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * Alflorone
   * F-COL
   * F-Cortef
   * Florinef
   * Fludrocortisone
   * Fludrocortone
   * Fluohydrisone
   * Fluohydrocortisone
   * 9-alpha-Fluorocortisol
   * Fluorocortisone
   * 9-alpha-Fluorohydrocortisone
   * 9-alpha-Fluoro-17-hydroxycorticosterone
   * 9-Fluoro-11-beta,17,21-trihydroxypregn-4-ene-3,20-dione
   * 9-alpha-Fluoro-11-beta,17-alpha,21-trihydroxy-4-pregnene-3,20-dione
   * U 5963
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 170 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 8750 ug/kg
SEX/DURATION            : female 7 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   JEMEAV Journal of Experimental Medicine.  (Rockefeller Univ. Press, 1230
   York Ave., New York, NY 10021)  V.1-    1896-  Volume(issue)/page/year:
   102,347,1955
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 100 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th
   International Committee on Laboratory Animals, Hanover, 1972," Speigel, A.
   ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973
   Volume(issue)/page/year: -,85,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 1 mg/kg
SEX/DURATION            : female 13-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th
   International Committee on Laboratory Animals, Hanover, 1972," Speigel, A.
   ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973
   Volume(issue)/page/year: -,85,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 2 mg/kg
SEX/DURATION            : female 13-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th
   International Committee on Laboratory Animals, Hanover, 1972," Speigel, A.
   ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973
   Volume(issue)/page/year: -,85,1973

                          *** STATUS IN U.S. ***
 
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***