*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TU5011500
CHEMICAL NAME           : Pregn-4-ene-3,20-dione, 17,21-dihydroxy-
CAS REGISTRY NUMBER     : 152-58-9
BEILSTEIN REFERENCE NO. : 2511358
REFERENCE               : 4-08-00-02913 (Beilstein Handbook Reference)
LAST UPDATED            : 199703
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C21-H30-O4
MOLECULAR WEIGHT        : 346.51
WISWESSER LINE NOTATION : L E5 B666 OV MUTJ A1 E1 FV1Q FQ
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Cortexolone
   * Cortisol, 11-dioxy-
   * Cortodoxone
   * 11-Deoxyhydrocortisone
   * 11-Deoxy-17-hydroxycorticosterone
   * 11-Desoxycortisol
   * 11-Desoxyhydrocortisone
   * 11-Desoxy-17-hydroxycorticosterone
   * 17,21-Dihydroxy-4-pregnene-3,20-dione
   * 17,21-Dihydroxyprogesterone
   * 11-Dioxycortisol
   * 17-alpha-Hydroxycortexone
   * 17-Hydroxy-11-deoxycorticosterone
   * NSC-18317
   * Reichstein's compound S
   * Reichstein's substance S
   * SKF 3050
   * Substance S
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#04684
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Human Liver
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 370,49,1996
 
                            *** END OF RECORD ***