*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TU4154085
CHEMICAL NAME           : Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-,
                          21-acetate
CAS REGISTRY NUMBER     : 125-10-0
BEILSTEIN REFERENCE NO. : 2342061
REFERENCE               : 4-08-00-03532 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C23-H28-O6
MOLECULAR WEIGHT        : 400.51
WISWESSER LINE NOTATION : L E5 B666 CV OV AHTTT&J A1 E1 FV1OV1 FQ
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * Cortancyl
   * delta'-Dehydrocortisone acetate
   * Delcortin
   * Delta-corlin
   * Deltalone
   * Ferrosan
   * Nisone
   * Prednisone acetate
   * Prednisone 21-acetate
   * 1,4-Pregnadien-17-alpha,21-diol-3,11,20-trione-21-acetate
   * Pregna-1,4-diene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 330 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   56,23,1980
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 135 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   56,23,1980

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X3270
       No. of Facilities: 18 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 1045 (estimated)
       No. of Female Employees: 1045 (estimated)

 
                            *** END OF RECORD ***