*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TU4153000
CHEMICAL NAME           : Pregna-1,4-diene-3,20-dione,
                          11-beta,17,21-trihydroxy-,
                          21-(4-(p-(bis(2-chloroethyl)amino) phenyl)butyrate)
CAS REGISTRY NUMBER     : 29069-24-7
BEILSTEIN REFERENCE NO. : 2826967
LAST UPDATED            : 199612
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C35-H45-Cl2-N-O6
MOLECULAR WEIGHT        : 646.71
WISWESSER LINE NOTATION : L E5 B666 OV AHTTT&J A1 CQ E1 FV1OV3R DN2G2G& FQ
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Chlorambucil ester of prednisolone
   * Chlorambucil prednisolone ester
   * LEO 1031
   * NSC 134087
   * Prednimustine
   * Prednisolone 21-(4-(p-(bis(2-chloroethyl)amino)phenyl)butyrate)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 16 mg/kg/4W
TOXIC EFFECTS :
   Behavioral - euphoria
   Blood - leukopenia
   Blood - thrombocytopenia
REFERENCE :
   JNMDBO Journal of Medicine (Westbury, NY).  (PJD Pub., Ltd., POB 966,
   Westbury, NY 11590) V.1-    1970-  Volume(issue)/page/year: 8,115,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 530 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   1,137,1976
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 128 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJCAAH European Journal of Cancer.  (Oxford, UK)  V.1-17(6), 1965-1981. For
   publisher information, see EJCODS.  Volume(issue)/page/year: 13,873,1977
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 128 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   EJCAAH European Journal of Cancer.  (Oxford, UK)  V.1-17(6), 1965-1981. For
   publisher information, see EJCODS.  Volume(issue)/page/year: 13,873,1977

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Inadequate Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 50,115,1990

   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 50,115,1990

   IARC Cancer Review:Group 3
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 50,115,1990

 
                            *** END OF RECORD ***