*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TU4146000
CHEMICAL NAME           : Pregna-1,4-diene-3,20-dione,
                          6-alpha-methyl-11-beta-17,21-trihydroxy-
CAS REGISTRY NUMBER     : 83-43-2
BEILSTEIN REFERENCE NO. : 2340300
REFERENCE               : 4-08-00-03498 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C22-H30-O5
MOLECULAR WEIGHT        : 374.52
WISWESSER LINE NOTATION : L E5 B666 OV AHTTT&J A1 CQ E1 FV1Q FQ L1
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Medrol
   * Medrol adt pak
   * Medrol dosepak
   * Medrone
   * delta(sup 1)-6-alpha-Methylhydrocortisone
   * Methylprednisolone
   * 6-alpha-Methylprednisolone
   * Metrisone
   * NSC-19987
   * Prednisolone, methyl-
   * Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-6-alpha-methyl-
   * 11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
   * 11-beta,17-alpha,21-Trihydroxy-6-alpha-methyl-1,4-pregnadiene-3,20-dione
   * Urbason
   * Urbasone
   * Wyacort
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2400 ug/kg
TOXIC EFFECTS :
   Cardiac - change in rate
   Lungs, Thorax, or Respiration - respiratory depression
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   BJANAD British Journal of Anesthesia.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1923-  Volume(issue)/page/year:
   69,422,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 60 mg/kg/3D-I
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
   Vascular - BP lowering not characterized in autonomic section
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   99,282,1983
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 20 mg/kg/45M-C
TOXIC EFFECTS :
   Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
   JRHUA9 Journal of Rheumatology.  (920 Yonge St., Suite 608, Toronto, Ont.,
   Canada)  V.1-    1974-  Volume(issue)/page/year: 13,477,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,832,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2292 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,832,1982
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 210 mg/kg/6W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes in urine composition
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Nutritional and Gross Metabolic - changes in sodium
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   1,305,1959

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 84067
       No. of Facilities: 33 (estimated)
       No. of Industries: 2
       No. of Occupations: 1
       No. of Employees: 272 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 84067
       No. of Facilities: 42 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 2047 (estimated)
       No. of Female Employees: 983 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***