*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TU4140000
CHEMICAL NAME           : Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-,
                          acetate mixed with 19-nor-17-alpha-
                          pregna-1,3,5(10)-trien-2-yne-3,17-diol
CAS REGISTRY NUMBER     : 8064-66-2
LAST UPDATED            : 198910
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C24-H32-O4.C20-H24-O2
MOLECULAR WEIGHT        : 681.00
COMPOUND DESCRIPTOR     : Tumorigen
                          Reproductive Effector
                          Human
                          Hormone
SYNONYMS/TRADE NAMES :
   * Ethynylestradiol-magestrol acetate
   * Ethinylestradiol mixed with megestrol acetate
   * Kombiquens
   * Megestrol acetate mixed with ethinyloestradiol
   * Megethinyl
   * Menoquens
   * Neodelpregnin
   * Oraconal
   * Serial
   * Tri-ervonum
   * Voldys
   * Volidan
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 10584 ug/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Blood - normocytic anemia
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,273,1980
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 41 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   4,496,1975
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 2430 ug/kg
SEX/DURATION            : female 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   1,1318,1963
 
                            *** END OF RECORD ***