*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TU4025000
CHEMICAL NAME           : Pregna-1,4-diene-3,20-dione,
                          6-alpha-fluoro-11-beta,17,21-trihydroxy-16-alpha-meth
                          yl-, 21-acetate
CAS REGISTRY NUMBER     : 1597-82-6
LAST UPDATED            : 199710
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C24-H31-F-O6
MOLECULAR WEIGHT        : 434.55
WISWESSER LINE NOTATION : L E5 B666 OV AHTTT&J A1 CQ E1 FV1OV1 FQ G1 LF
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * 21-Acetyl-6-alpha-fluoro-16-alpha-methylprednisolone
   * Alondra
   * Cortidene
   * Dilar
   * 6-alpha-Fluoro-16-alpha-methylprednisolone 21-acetate
   * Haldrate
   * Haldrone
   * 16-alpha-Methyl-6-alpha-fluoro-prednisolone-21-acetate
   * Monocortin
   * Paramethasone acetate
   * Paramethasone 21-acetate
   * Sintecort
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 392 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,588,1982
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10500 ug/kg
SEX/DURATION            : female 1-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   NFGZAD Nippon Funin Gakkai Zasshi.  Japanese Journal of Fertility and
   Sterility.  (Nippon Funin Gakkai, 1-1 Sadohara-cho, Ichigaya, Shinjuku-ku,
   Toyko 162, Japan)  V.1-    1956-  Volume(issue)/page/year: 13,211,1968
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2625 ug/kg
SEX/DURATION            : female 1-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
REFERENCE :
   NFGZAD Nippon Funin Gakkai Zasshi.  Japanese Journal of Fertility and
   Sterility.  (Nippon Funin Gakkai, 1-1 Sadohara-cho, Ichigaya, Shinjuku-ku,
   Toyko 162, Japan)  V.1-    1956-  Volume(issue)/page/year: 13,211,1968

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - A1177
       No. of Facilities: 33 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 297 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***