*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TU3950000
CHEMICAL NAME           : Pregna-1,4-diene-2,20-dione,
                          9-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-,
                          16,21-diacetate
CAS REGISTRY NUMBER     : 67-78-7
LAST UPDATED            : 199710
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C25-H31-F-O8
MOLECULAR WEIGHT        : 478.56
WISWESSER LINE NOTATION : T F5 E5 B666 GO IO RV AHTTTT&J A1 BF COV1 E1 FV1OV1
                          H1 H1
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Aristocort diacetate
   * Aristocort forte parenteral
   * Aristocort syrup
   * 9-alpha-Fluoro-16-alpha-hydroxyprednisolone diacetate
   * 9-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione  
   16,21-diacetate
   * Kenacort diacetate syrup
   * Triamcinolone diacetate
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 87500 ug/kg
SEX/DURATION            : female 15-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
REFERENCE :
   BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1947- Volume(issue)/page/year:
   385,257,1975
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 3200 ug/kg
SEX/DURATION            : female 11-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   149,862,1965

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 81555
       No. of Facilities: 44 (estimated)
       No. of Industries: 1
       No. of Occupations: 4
       No. of Employees: 1469 (estimated)
       No. of Female Employees: 1098 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***