*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TU3930000
CHEMICAL NAME           : Pregna-1,4-diene-3,20-dione,
                          9-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-, cyclic
                          16,17-acetal with acetone, 21-(3,3-dimethylbutyrate)
CAS REGISTRY NUMBER     : 5611-51-8
BEILSTEIN REFERENCE NO. : 1413888
REFERENCE               : 5-19-06-00569 (Beilstein Handbook Reference)
LAST UPDATED            : 199712
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C30-H41-F-O7
MOLECULAR WEIGHT        : 532.71
WISWESSER LINE NOTATION : T F5 E5 B666 GO IO RV AHTTTT&J A1 BF CQ E1
                          FV1OV1X1&1&1 H1 H1
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * Aristospan
   * CL 34433
   * Lederspan
   * TATBA
   * Triamcinolone hexacetonide
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 40 mg/kg
SEX/DURATION            : female 10-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
REFERENCE :
   JOANAY Journal of Anatomy.  (Cambridge Univ. Press, 32 E. 57th St., New
   York, NY 10022) V.51-    1916-  Volume(issue)/page/year: 128,747,1979
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 40 mg/kg
SEX/DURATION            : female 10-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   JOANAY Journal of Anatomy.  (Cambridge Univ. Press, 32 E. 57th St., New
   York, NY 10022) V.51-    1916-  Volume(issue)/page/year: 128,747,1979
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   46IEAC "Current Research Trends in Prenatal Craniofacial Development,
   Proceedings of an International Conference, 1980," Pratt, R.M., and R.L.
   Christiansen, eds., New York, Elsevier Science Pub. Co., Inc., 1980
   Volume(issue)/page/year: -,387,1980
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - skin and skin
   appendages
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JDREAF Journal of Dental Research.  (International Assoc. for Dental
   Research, 734 15th St., NW, Suite 809, Washington, DC 20005)  V.1-    1919-
   Volume(issue)/page/year: 58(Spec Iss A),384,197
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   IMNGBK Immunogenetics.  (Springer-Verlag New York, Inc., Service Center, 44
   Hartz Way, Secaucus, NJ 07094)  V.1-    1974-  Volume(issue)/page/year:
   13,443,1981

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5557
       No. of Facilities: 17 (estimated)
       No. of Industries: 1
       No. of Occupations: 3
       No. of Employees: 1088 (estimated)
       No. of Female Employees: 744 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***