*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TU3832500
CHEMICAL NAME           : Pregna-1,4-diene-3,20-dione,
                          6-alpha-fluoro-11-beta,21-dihydroxy-16-alpha-methyl-
CAS REGISTRY NUMBER     : 152-97-6
BEILSTEIN REFERENCE NO. : 3122594
LAST UPDATED            : 199612
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C22-H29-F-O4
MOLECULAR WEIGHT        : 376.51
WISWESSER LINE NOTATION : L E5 B666 OV AHTTT&J A1 CQ E1 FV1Q G1 LF
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * Flucortolone
   * Fluocortolon
   * Fluocortolone
   * Fluorcortolone
   *   6-alpha-Fluoro-11-beta,21-dihydroxy-16-alpha-methylpregna-1,4-diene-3,20
     -dione
   * 6-alpha-Fluoro-16-alpha-methyl-1-dehydrocorticosterone
   * 6-alpha-Fluoro-16-alpha-methylpregna-1,4-diene-11-beta,21-diol-3,20-dione
   * 6-alpha-Fluoro-16-alpha-methyl-delta(sup  
   1,4)-pregnadiene-11-beta-diol-3,20-dione
   * SH 742
   * Ultralan oral
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 70 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   YKRYAH Yakubutsu Ryoho.  Medicinal Treatment.  (Tokyo, Japan)  V.1-14,
   1968-81.  Suspended.  Volume(issue)/page/year: 9,1623,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 20 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   YKRYAH Yakubutsu Ryoho.  Medicinal Treatment.  (Tokyo, Japan)  V.1-14,
   1968-81.  Suspended.  Volume(issue)/page/year: 9,1623,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 70 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   YKRYAH Yakubutsu Ryoho.  Medicinal Treatment.  (Tokyo, Japan)  V.1-14,
   1968-81.  Suspended.  Volume(issue)/page/year: 9,1623,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 70 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   YKRYAH Yakubutsu Ryoho.  Medicinal Treatment.  (Tokyo, Japan)  V.1-14,
   1968-81.  Suspended.  Volume(issue)/page/year: 9,1623,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 2500 ug/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   AMBED4 AMI-Berichte.  (Berlin, Fed. Rep. Ger.)  No. 1-2, 1978-82.
   Volume(issue)/page/year: (1),127,1988
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 30 mg/kg
SEX/DURATION            : female 7-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   YKRYAH Yakubutsu Ryoho.  Medicinal Treatment.  (Tokyo, Japan)  V.1-14,
   1968-81.  Suspended.  Volume(issue)/page/year: 10,151,1977
 
                            *** END OF RECORD ***