*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TU3832200
CHEMICAL NAME           : Pregna-1,4-diene-3,20-dione,
                          11,17-dihydroxy-21-((3,7,11-trimethyl-1-oxo-2,6,10-
                          dodecatrienyl)-oxy)-, (11beta,21(2E,6E))-
CAS REGISTRY NUMBER     : 118244-44-3
LAST UPDATED            : 199306
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C36-H50-O6
MOLECULAR WEIGHT        : 578.86
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Prednisolone farnesylate
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1456 mg/kg/13W-I
TOXIC EFFECTS :
   Endocrine - changes in spleen weight
   Blood - changes in leukocyte (WBC) count
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 17(Suppl
   3),49,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 728 mg/kg/52W-I
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), zonal
   Endocrine - changes in spleen weight
   Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 17(Suppl
   3),91,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2730 mg/kg/13W-I
TOXIC EFFECTS :
   Blood - changes in leukocyte (WBC) count
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
   Related to Chronic Data - death
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 17(Suppl
   3),1,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 291 mg/kg/13W-I
TOXIC EFFECTS :
   Endocrine - changes in adrenal weight
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 17(Suppl
   3),123,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 291 mg/kg/52W-I
TOXIC EFFECTS :
   Endocrine - changes in adrenal weight
   Blood - changes in leukocyte (WBC) count
   Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 17(Suppl
   3),161,1992
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : >11 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
   Reproductive - Specific Developmental Abnormalities - hepatobiliary system
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 17(Suppl
   3),217,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 3250 ug/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 17(Suppl
   3),241,1992
 
                            *** END OF RECORD ***