*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TU3722500
CHEMICAL NAME           : Pregna-1,4-diene-3,20-dione,
                          17,21-bis(1-oxopropoxy)-,
                          9-fluoro-11-hydroxy-16-methyl- (11beta,16beta)-,
                          mixt. with
                          O-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopy
                          ranosyl-
                          (1-6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glyce
                          ro-hex-4-enopyranosyl -(1-4))-2-deoxy- D-streptamine
                          sulfate (2:5) (salt)
CAS REGISTRY NUMBER     : 137857-13-7
LAST UPDATED            : 199603
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C56-H74-F2-O14.C38-H74-N10-O14.5H2-O4-S
MOLECULAR WEIGHT        : 2394.92
SYNONYMS/TRADE NAMES :
   * Betamethasone dipropionate mixt. with sisomicin sulfate
   * DS-2630
   * Sisomicin sulfate mixt. with betamethasone dipropionate
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 149 mg/kg/13W-I
TOXIC EFFECTS :
   Endocrine - changes in thymus weight
   Blood - changes in leukocyte (WBC) count
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 27,4013,1993
 
                            *** END OF RECORD ***