*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : TU3686000
CHEMICAL NAME : Pregna-1,4-diene-3,20-dione,
21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-,
(11-beta,16-beta)-, mixt. with
(11-beta,16-beta)-9-fluoro-11,17-dihydroxy-16-methyl-
21-(phosphonooxy)pregna-1,4-diene-3,20-dione disodium
salt
CAS REGISTRY NUMBER : 8064-08-2
OTHER CAS REGISTRY NOS. : 12797-73-8
LAST UPDATED : 198910
DATA ITEMS CITED : 5
MOLECULAR FORMULA : C24-H31-F-O6.C22-H30-F-O8-P.2Na
MOLECULAR WEIGHT : 953.02
WISWESSER LINE NOTATION : L E5 B666 OV AHTTT&J A1 BF CQ E1 FV1OV1 FQ G1 &L E5
B666 OV AHTTT&J A1 BF CQ E1 FV1OPWO FQ G1
COMPOUND DESCRIPTOR : Reproductive Effector
Hormone
SYNONYMS/TRADE NAMES :
* Betamethasone acetate mixed with betamethasone sodium phosphate
* Betamethasone sodium phosphate mixed with betamethasone acetate
* Celestan-depot
* Celestone chronodose
* Celestone solospan
* Celestone soluspan
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 1800 ug/kg
SEX/DURATION : female 12-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 23,15,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 4200 ug/kg
SEX/DURATION : female 12-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 23,15,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rabbit
DOSE : 800 ug/kg
SEX/DURATION : female 24-26 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
Reproductive - Effects on Newborn - physical
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
Volume(issue)/page/year: 136,234,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rabbit
DOSE : 200 ug/kg
SEX/DURATION : female 26 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - live birth index (measured after birth)
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211,
1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year:
574,197,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rabbit
DOSE : 200 ug/kg
SEX/DURATION : female 26 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - respiratory system
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211,
1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year:
574,197,1979
*** END OF RECORD ***