*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TS5505000
CHEMICAL NAME           : 2,18-Porphinedipropionic acid,
                          7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-,
                          dihydrochloride
CAS REGISTRY NUMBER     : 17696-69-4
LAST UPDATED            : 199701
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C34-H38-N4-O6.2Cl-H
MOLECULAR WEIGHT        : 671.68
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Acido 1,3,5,8-tetrametil-2,4-bis(idrossietil)porpfina-6,7-dipropionico  
   dicloridrato
   * 7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphinedipropionic  
   acid 2HCl
   * Ematoporfirina
   * Hematoporphyrin dihydrochloride
   * Hematoporphyrin IX dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   117,145,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 278 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - changes in motor activity (specific assay)
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   117,145,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   117,145,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 169 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - changes in motor activity (specific assay)
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   117,145,1978

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***