*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP8710000
CHEMICAL NAME           : Podocarpa-8,11,13-trien-15-oic acid, 13-isopropyl-
CAS REGISTRY NUMBER     : 1740-19-8
BEILSTEIN REFERENCE NO. : 2059290
REFERENCE               : 4-09-00-02389 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C20-H28-O2
MOLECULAR WEIGHT        : 300.48
SYNONYMS/TRADE NAMES :
   * Abietic acid, dehydro-
   * Dehydroabietic acid
   * (-)-Dehydroabietic acid
   * 13-Isopropylpodocarpa-8,11,13-trien-15-oic acid
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1710 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - other (direct) parasympathomimetic
   Behavioral - ataxia
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 18,42,1977
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8400 mg/kg/28D-C
TOXIC EFFECTS :
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
   etc.)
   Biochemical - Metabolism (Intermediary) - Plasma proteins not involving
   coagulation
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 18,42,1977

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M2653
       No. of Facilities: 1630 (estimated)
       No. of Industries: 16
       No. of Occupations: 20
       No. of Employees: 13811 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M2653
       No. of Facilities: 394 (estimated)
       No. of Industries: 8
       No. of Occupations: 12
       No. of Employees: 14625 (estimated)
       No. of Female Employees: 4688 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***