*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TR1312000
CHEMICAL NAME           : Polymyxin E1, 1-de(N(sup
                          2)-(6-methyl-1-oxooctyl)-L-2,4-diaminobutanoic
                          acid)-2-(N-(1- oxohexyl)-L-threonine)-, hydrochloride
CAS REGISTRY NUMBER     : 51887-95-7
LAST UPDATED            : 199306
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C46-H86-N14-O12.Cl-H
MOLECULAR WEIGHT        : 1063.92
SYNONYMS/TRADE NAMES :
   * n-Hexanoyl colistin nonapeptide hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 74 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABCHA6 Agricultural and Biological Chemistry.  (Maruzen Co. Ltd., POB 5050,
   Tokyo International, Tokyo 100-31, Japan)  V.25-    1961-
   Volume(issue)/page/year: 37,2709,1973
 
                            *** END OF RECORD ***