*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2514000
CHEMICAL NAME           : Platycodin
SUBSTANCE DEFINITION :
   A saponin fraction isolated from Platycodi radix, the roots of Platycodon
   grandiflorum A.
REFERENCE :
   YAHOA3 Yakhak Hoe Chi.  Journal of the Pharmaceutical Society.  (Taehan
   Yakkakhoe, c/o College of Pharmacy, Seoul National Univ., Seoul 151, S.
   Korea)  V.1-    1956(?)-
LAST UPDATED            : 199506
DATA ITEMS CITED        : 5
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Crude platycodin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >800 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 92,951,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 92,951,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 420 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   YAHOA3 Yakhak Hoe Chi.  Journal of the Pharmaceutical Society.  (Taehan
   Yakkakhoe, c/o College of Pharmacy, Seoul National Univ., Seoul 151, S.
   Korea)  V.1-    1956(?)-  Volume(issue)/page/year: 19(3),164,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   YAHOA3 Yakhak Hoe Chi.  Journal of the Pharmaceutical Society.  (Taehan
   Yakkakhoe, c/o College of Pharmacy, Seoul National Univ., Seoul 151, S.
   Korea)  V.1-    1956(?)-  Volume(issue)/page/year: 19(3),164,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 92,951,1972
 
                            *** END OF RECORD ***