*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2507100
CHEMICAL NAME           : Platinum,
                          tetraamine(mu-(1,4,7,10,13,16-hexaoxacyclooctadecane-
                          2,3,11,12-tetracarbox ylato(4-)-O(sup 2),O(sup
                          3),O(sup 11),O(sup 12))di-
CAS REGISTRY NUMBER     : 128163-25-7
LAST UPDATED            : 199709
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C16-H32-N4-O14-Pt2
MOLECULAR WEIGHT        : 894.70
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 18-Crown-6-tetracarboxybis-diammineplatinum(II)
   * CTDP
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   EJCAEL European Journal of Cancer.  (Pergamon Press, c/o Elsevier Science,
   660 White Plains Rd., Tarrytown, NY 10591)  V.26-28(2/3), 1990-92.  For
   publisher information, see EJCTEA  Volume(issue)/page/year: 27,62,1991
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Ovary
DOSE/DURATION           : 20 umol/L
REFERENCE :
   EJCAEL European Journal of Cancer.  (Pergamon Press, c/o Elsevier Science,
   660 White Plains Rd., Tarrytown, NY 10591)  V.26-28(2/3), 1990-92.  For
   publisher information, see EJCTEA  Volume(issue)/page/year: 27,62,1991
 
                            *** END OF RECORD ***