*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2501000
CHEMICAL NAME           : Platinum (II), dipyrrolidinedichloro-, cis-
CAS REGISTRY NUMBER     : 38780-42-6
LAST UPDATED            : 199806
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C8-H18-Cl2-N2-Pt
MOLECULAR WEIGHT        : 408.27
WISWESSER LINE NOTATION : T5MTJ 2 &G-PT-G -C
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * cis-Bis(pyrrolidine)dichloroplatinum (II)
   * cis-Dichlorobis(pyrrolidine)platinum (II)
   * cis-Dipyrrolidinedichloroplatinum (II)
   * Platinum (II), bis(pyrrolidine)dichloro-, cis-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 240 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   11,145,1975
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 89 mg/kg/6W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
   Endocrine - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,913,1979
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 nmol/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,913,1979
 
                            *** END OF RECORD ***