*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2497220
CHEMICAL NAME           : Platinum (II),
                          dichloro(4-methyl-o-phenylenediammine)-
CAS REGISTRY NUMBER     : 57948-13-7
LAST UPDATED            : 199712
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C7-H10-Cl2-N2-Pt
MOLECULAR WEIGHT        : 388.18
WISWESSER LINE NOTATION : ZR BZ D1 &G-PT-G
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Dichloro(4-methyl-o-phenylenediammine)platinum(II)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   RCRVAB Russian Chemical Reviws (English Translation).  Translation of
   USKHAB.  (Royal Soc. of Chemistry, Distribution Centre, Blackhorse Rd.,
   Letchworth, Herts SG6 1HN, UK) V.29-    1960-  Volume(issue)/page/year:
   50,353,1981
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 2500 nmol/L
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 23,459,1980
 
                            *** END OF RECORD ***