*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : TP2497100
CHEMICAL NAME : Platinum(II), dichloro(ethylenediammine)-, (SP-4-2)-
CAS REGISTRY NUMBER : 14096-51-6
LAST UPDATED : 199410
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C2-H8-Cl2-N2-Pt
MOLECULAR WEIGHT : 326.11
WISWESSER LINE NOTATION : Z2Z &G-PT-G
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* cis-Dichloroethylenediamineplatinum(II)
* Platinum, dichloro(1,2-ethanediamine-N,N')-, (SP-4-2)-
* Platinum, dichloro(ethylenediammine)-, cis-
* Pt-05
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 14 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BICHBX Bioinorganic Chemistry. (New York, NY) V.1-9, 1971-78.
Volume(issue)/page/year: 2,187,1973
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 2 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 77,45,1980
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 33 umol/L
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
1957- Volume(issue)/page/year: 34,379,1987
TYPE OF TEST : DNA adduct
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 1 mmol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
16,39,1977
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 1 ug/plate
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
Volume(issue)/page/year: 90,209,1979
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 25 umol/L
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
Volume(issue)/page/year: 6,207,1970
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 25 umol/L
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
Volume(issue)/page/year: 6,207,1970
TYPE OF TEST : DNA adduct
TEST SYSTEM : Mammal - species unspecified Lymphocyte
DOSE/DURATION : 50 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
10,27,1975
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Mammal - species unspecified Lymphocyte
DOSE/DURATION : 10 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
23,1659,1974
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Mammal - species unspecified Lymphocyte
DOSE/DURATION : 10 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
23,1659,1974
*** END OF RECORD ***