*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2494900
CHEMICAL NAME           : Platinum(II),
                          dichloro(4,5-dimethyl-o-phenylenediammine)-,
                          (SP-4-2)-
CAS REGISTRY NUMBER     : 40580-75-4
LAST UPDATED            : 199410
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C8-H12-Cl2-N2-Pt
MOLECULAR WEIGHT        : 402.21
WISWESSER LINE NOTATION : ZR BZ D1 E1 &G-PT-G
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * cis-Dichloro(4,5-dimethyl-o-phenylenediammine)platinum (II)
   * Platinum (II), dichloro(4,5-dimethyl-o-phenylenediammine) (Z)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 283 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   11,145,1975
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10200 nmol/L
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 23,459,1980
 
                            *** END OF RECORD ***