*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2275840
CHEMICAL NAME           : Platinum,
                          (1,2-cyclohexanediamine-N,N')bis(neodecanoato-O)-,
                          (SP-4-2-(1R-trans))-
CAS REGISTRY NUMBER     : 114488-24-3
LAST UPDATED            : 199103
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C26-H52-N2-O4-Pt
MOLECULAR WEIGHT        : 651.89
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclo hexaneplatinum(II)
   * (1,2-Cyclohexanediamine-N,N')bis(neodecanoato-O)platinum  
   (SP-4-2-(1R-trans))
   * L-Nddp
   * Platinum, bis(neodecanoato)(trans-1,2-cyclohexanediammine)-, (Z)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 60500 ug/kg
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), zonal
   Kidney, Ureter, Bladder - renal function tests depressed
   Blood - granulocytopenia
REFERENCE :
   CCPHDZ Cancer Chemotherapy and Pharmacology.  (Springer-Verlag New York,
   Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1978-
   Volume(issue)/page/year: 24,1,1989
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 225 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Blood - hemorrhage
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   CCPHDZ Cancer Chemotherapy and Pharmacology.  (Springer-Verlag New York,
   Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1978-
   Volume(issue)/page/year: 24,1,1989
 
                            *** END OF RECORD ***