*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2205000
CHEMICAL NAME           : Platinum (II), bis(cyclooctylammine)dichloro-, cis-
CAS REGISTRY NUMBER     : 62928-48-7
LAST UPDATED            : 199012
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C16-H34-Cl2-N2-Pt
MOLECULAR WEIGHT        : 520.51
WISWESSER LINE NOTATION : L8TJ AZ 2 &G-PT-G -C
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * cis-Dicyclooctylamminedichloroplatinum (II)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 660 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes
   Tumorigenic - facilitates action of known carcinogen
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   11,145,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RRCRBU Recent Results in Cancer Research.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1965-
   Volume(issue)/page/year: 48,113,1974
 
                            *** END OF RECORD ***