*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TP2171500
CHEMICAL NAME           : Platinum(II), (1,2-benzenediamine-N,N')dichloro-,
                          (SP-4-2)-
CAS REGISTRY NUMBER     : 38780-39-1
LAST UPDATED            : 199410
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C6-H8-Cl2-N2-Pt
MOLECULAR WEIGHT        : 374.15
WISWESSER LINE NOTATION : ZR BZ &G-PT-G -Z
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * cis-Dichloro(1,2-diaminobenzene)platinum(II)
   * cis-Dichloro(o-phenylenediamine)platinum (II)
   * Platinum(II), dichloro(o-phenylenediammine)-, (Z)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 48 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes
   Tumorigenic - facilitates action of known carcinogen
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   11,145,1975
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 2300 nmol/L
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 23,459,1980
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 2500 nmol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   29,327,1980
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 umol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   29,327,1980
 
                            *** END OF RECORD ***