*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BU4630000
CHEMICAL NAME           : Amsinckia intermedia
SUBSTANCE DEFINITION :
   The seeds containing pyrrolizidine alkaloids are from Amsinckia intermedia
   Fisch and Mey
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.
LAST UPDATED            : 199506
DATA ITEMS CITED        : 3
COMPOUND DESCRIPTOR     : Tumorigen
                          Reproductive Effector
                          Natural Product
SYNONYMS/TRADE NAMES :
   * A. Intermedia
   * Fiddle-neck
   * Seed of fiddleneck
   * Tarweed
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAVMA4 Journal of the American Veterinary Medical Association.  (American
   Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196)  V.48-
   1915-  Volume(issue)/page/year: 150,1305,1967
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 275 gm/kg
                          female 1-22 day(s) after conception
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - transplacental tumorigenesis
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   47,1037,1971

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   CTRRDO Cancer Treatment Reports.  (Washington, DC)  V.60-71, 1976-87.  For
   publisher information,  see JNCIEQ.  Volume(issue)/page/year: 60,1171,1976

 
                            *** END OF RECORD ***