*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BU2811000
CHEMICAL NAME           : Amphotericin B, N-D-ornithyl-, methyl ester
CAS REGISTRY NUMBER     : 76023-49-9
LAST UPDATED            : 199312
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C53-H85-N3-O18
MOLECULAR WEIGHT        : 1052.41
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Amphotericin B, N-(2,5-diamino-1-oxopentyl)-, methyl ester, (3'(R))-
   * N-D-Ornithylamphotericin B methyl ester
   * Sch 28191
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 35,911,1982
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 392 mg/kg/14W-I
TOXIC EFFECTS :
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Blood - changes in erythrocyte (RBC) count
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   5,737,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 910 mg/kg/13W-I
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Kidney, Ureter, Bladder - urine volume increased
   Blood - changes in erythrocyte (RBC) count
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   5,737,1985
 
                            *** END OF RECORD ***