*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BU2700000
CHEMICAL NAME           : Amphotericin B, methyl ester
CAS REGISTRY NUMBER     : 36148-89-7
LAST UPDATED            : 199506
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C48-H75-N-O17
MOLECULAR WEIGHT        : 938.24
WISWESSER LINE NOTATION : T6-36- A AO RVO A&U C&U E&U G&U I&U K&U M&UTJ CVO1 DQ
                          FQ HQ JQ KQ NQ PQ T1 U1 VQ W1 O&O- BT6O
COMPOUND DESCRIPTOR     : Drug
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 64,462,1975
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 300 mg/kg/30D-I
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 10,687,1976
 
                            *** END OF RECORD ***