*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : AC3662000
CHEMICAL NAME : Acetamide,
N-(4-((2-hydroxy-5-methylphenyl)azo)phenyl)-
CAS REGISTRY NUMBER : 2832-40-8
BEILSTEIN REFERENCE NO. : 0753492
LAST UPDATED : 199710
DATA ITEMS CITED : 26
MOLECULAR FORMULA : C15-H15-N3-O2
MOLECULAR WEIGHT : 269.33
WISWESSER LINE NOTATION : QR D BNUNR DMV1
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* 4-Acetamido-2'-hydroxy-5'-methylazobenzene
* Acetamine Yellow CG
* Acetate Fast Yellow G
* Acetoquinone Light Yellow
* Acetoquinone Light Yellow 4JLZ
* Altco Sperse Fast Yellow GFN New
* Amacel Yellow G
* Artisil Direct Yellow G
* Artisil Yellow G
* Artisil Yellow 2GN
* Calcosyn Yellow GC
* Calcosyn Yellow GCN
* Celliton Discharge Yellow GL
* Celliton Fast Yellow G
* Celliton Fast Yellow GA
* Celliton Fast Yellow GA-CF
* Celliton Yellow G
* Celutate Yellow GH
* C.I. 11855
* C.I. 3/11855
* Cibacete Yellow GBA
* Cibacet Yellow GBA
* Cibacet Yellow 2GC
* C.I. Disperse Yellow 3
* Cilla Fast Yellow G
* C.I. Solvent Yellow 77
* CI Solvent Yellow 92
* CI Solvent Yellow 99
* Diacelliton Fast Yellow G
* Disperse Fast Yellow G
* Disperse Yellow G
* Disperse Yellow 3
* Dispersive Yellow 3T
* Disperse Yellow Z
* Dispersol Fast Yellow G
* Dispersol Printing Yellow G
* Dispersol Yellow A-G
* Durgacet Yellow G
* Durosperse Yellow G
* Eastone Yellow GN
* Esteroquinone Light Yellow 4JL
* Estone Yellow GN
* Fenacet Fast Yellow G
* Fenacet Yellow G
* Genacron Yellow G
* Hispacet Fast Yellow G
* Hisperse Yellow G
* N-(4-((2-Hydroxy-5-methylphenyl)azo)phenyl)acetamide
* 4'-((6-Hydroxy-m-tolyl)azo)acetanilide
* Interchem Acetate Yellow G
* Interchem Disperse Yellow GH
* Intraperse Yellow GBA
* Intrasperse Yellow GBA Extra
* Kayalon Fast Yellow G
* Kayaset Yellow G
* Kca Acetate Fast Yellow G
* Microsetile Yellow GR
* Miketon Fast Yellow G
* Nacelan Fast Yellow CG
* NCI-C53781
* Novalon Yellow 2GN
* Nyloquinone Light Yellow 4JL
* Nyloquinone Yellow 4J
* Ostacet Yellow P2G
* Palacet Yellow GN
* Palanil Yellow G
* Pamacel Yellow G-3
* Perliton Yellow G
* Reliton Yellow C
* Resiren Yellow TG
* Safaritone Yellow G
* Samaron Yellow PA3
* Serinyl Hosiery Yellow GD
* Seriplas Yellow GD
* Serisol Fast Yellow GD
* Setacyl Yellow G
* Setacyl Yellow 2GN
* Setacyl Yellow P-2GL
* Silotras Yellow TSG
* Supracet Fast Yellow G
* Synten Yellow 2G
* Synton Yellow 2G
* Terasil Yellow GBA Extra
* Terasil Yellow 2GC
* Tertranese Yellow N-2GL
* Tuladisperse Fast Yellow 2G
* Vonteryl Yellow G
* Vonteryl Yellow R
* Yellow reliton G
* Yellow Z
* Zlut disperzni 3
* Zlut rozpoustedlova 77
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >14 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 53(10),93,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8190 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Cardiac - other changes
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 53(10),92,1988
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >14 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 53(10),93,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8080 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Cardiac - other changes
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 53(10),92,1988
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 35 gm/kg/14D-C
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-222,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 168 gm/kg/14D-C
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-222,1982
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 180 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Blood - leukemia
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-222,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 433 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-222,1982
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 216 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Lungs, Thorax, or Respiration - bronchiogenic carcinoma
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-222,1982
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 216 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Blood - leukemia
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-222,1982
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 10 ug/plate
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
236,933,1987
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 10 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
12,85,1988
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 5 mg/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
236,933,1987
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Amphibian - frog
DOSE/DURATION : 28 gm/L
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
Volume(issue)/page/year: 25,175,1979
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 48,149,1990
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 8,97,1975
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 8,97,1975
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 48,149,1990
TOXICOLOGY REVIEW
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 15,311,1996
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2104
No. of Facilities: 164 (estimated)
No. of Industries: 8
No. of Occupations: 17
No. of Employees: 3929 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M2104
No. of Facilities: 516 (estimated)
No. of Industries: 9
No. of Occupations: 16
No. of Employees: 20479 (estimated)
No. of Female Employees: 1215 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NTP Carcinogenesis Bioassay (feed);clear evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-222,82
*** END OF RECORD ***