*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AC3350000
CHEMICAL NAME           : Acetamide, N-(3-hydroxyfluoren-2-yl)-
CAS REGISTRY NUMBER     : 1838-56-8
BEILSTEIN REFERENCE NO. : 2811033
REFERENCE               : 4-13-00-02239 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C15-H13-N-O2
MOLECULAR WEIGHT        : 239.29
WISWESSER LINE NOTATION : L B656 HHJ CQ KMV1
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 3-HO-AAF
   * 3-Hydroxy-N-acetyl-2-aminofluorene
   * N-(3-Hydroxy-2-fluorenyl)acetamide
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 96 mg/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   17,383,1975
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   6,21,1979
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 9,284,1972

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: E coli polA with S9; Histidine
   reversion-Ames test
   
   EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; S
   cerevisiae-homozygosis
   
   EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
   
   EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal

 
                            *** END OF RECORD ***