*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AB6310000
CHEMICAL NAME           : Acetamide,
                          N-(2,4-dibromo-6-((cyclohexylmethylamino)methyl)pheny
                          l)-2-(2-methoxyphenox y)-, monohydrochloride
CAS REGISTRY NUMBER     : 71420-31-0
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C23-H28-Br2-N2-O3.Cl-H
MOLECULAR WEIGHT        : 576.81
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   2-Guaiacolglycolylamino-3,5-dibromo-N-cyclohexyl-N-methylbenzenemethanam
     ine hydrochloride
   * N-(2-Guajakol-glykolyl-amino-3,5-dibrombenzyl)-N-cyclohexyl-methylamin
   * N-(Guayacolglycolylamino)bromhexine hydrochloride
   * IFT 1026
   * N-(2-(Methoxyphenoxy)acetoxy)bromhexine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - stiffness
REFERENCE :
   FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy)
   V.8-43    1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 34,243,1979
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3600 mg/kg/8D-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy)
   V.8-43    1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 34,243,1979
 
                            *** END OF RECORD ***